Contextual fear conditioning induces differential alternative splicing
نویسندگان
چکیده
منابع مشابه
Contextual fear conditioning in zebrafish.
Zebrafish are a genetically tractable vertebrate that hold considerable promise for elucidating the molecular basis of behavior. Although numerous recent advances have been made in the ability to precisely manipulate the zebrafish genome, much less is known about many aspects of learning and memory in adult fish. Here, we describe the development of a contextual fear conditioning paradigm using...
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The present study examined the role of ovarian steroids in contextual fear conditioning and hippocampal synaptic plasticity in female rats. In experiment 1, adult female rats were ovariectomized and submitted to contextual fear conditioning, a procedure in which rats received unsignaled footshock in a novel observation chamber; freezing behavior served as the measure of conditional fear. Ovarie...
متن کاملPrefrontal neuronal circuits of contextual fear conditioning.
Over the past years, numerous studies have provided a clear understanding of the neuronal circuits and mechanisms involved in the formation, expression and extinction phases of conditioned cued fear memories. Yet, despite a strong clinical interest, a detailed understanding of these memory phases for contextual fear memories is still missing. Besides the well-known role of the hippocampus in en...
متن کاملDifferential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear-conditioning.
The hippocampus is an essential neural structure in developing contextual memory in a situation in which rapid development of associative learning should occur. We tested a subregion-specific contribution in the hippocampus to memory acquisition and retrieval, using the contextual fear-conditioning paradigm. The current results suggest that all three subregions (i.e., CA3, CA1, and dentate gyru...
متن کاملDifferential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
The contribution of the amygdala and hippocampus to the acquisition of conditioned fear responses to a cue (a tone paired with footshock) and to context (background stimuli continuously present in the apparatus in which tone-shock pairings occurred) was examined in rats. In unoperated controls, responses to the cue conditioned faster and were more resistant to extinction than were responses to ...
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ژورنال
عنوان ژورنال: Neurobiology of Learning and Memory
سال: 2016
ISSN: 1074-7427
DOI: 10.1016/j.nlm.2016.07.018